Job Description
Note: The job is a remote job and is open to candidates in USA. Invivyd is a company dedicated to delivering protection from serious viral infectious diseases, particularly for immunocompromised populations. They are seeking a Structural Evolutionary Biologist to join their Research and Development Team, responsible for building computational tools and analyzing viral sequencing data to inform therapeutic monoclonal antibody development. Responsibilities • Lead an effort that coordinates inputs from microbiologists, evolutionary biologists and antibody engineers to guide programming efforts to develop bioinformatic tools for use in antibody discovery and development • Analyze large sequence datasets to identify evolutionary trends, structural constraints, variant hotspots, and functional motifs in multiple viral target proteins • Develop, maintain, and optimize computational pipelines for sequence processing, structural prediction, phylogenetic analysis, and evolutionary modeling • Curate wastewater and clinical sequence database connectivity pipelines • Support protein engineering and antibody programs by providing structural and evolutionary risk assessments and actionable insights • Generate figures and animations that effectively communicate observed trends in virus evolution and target structural dynamics • Author non-clinical study reports related to pathogen surveillance in support of regulatory filings • Serve as primary point of contact for collaborations and contracts with external partners • Manage a team of programmers and developers • Collaborate closely with cross-functional teams, including other research and development groups, preclinical, clinical and regulatory teams Skills • PhD in a relevant scientific discipline (e.g., Computational Biology, Evolutionary Biology, Molecular Biology, Structural Biology, Biochemistry, Immunology, Microbiology) • Demonstrated expertise in microbial molecular evolution, sequence analysis, and phylogenetics • Experience working with large biological data sets and establishing quality assessment workflows for regularly updated databases • Programming skills in Python and JavaScript • Proficiency in design and maintenance of customized computational biology tools and cloud-based bioinformatics suites • Experience in managing CROs and external collaborations, including budgeting and timeline management • Strong problem-solving skills and the ability to adapt to evolving project needs • Excellent verbal and written communication skills • Ability to work independently as well as part of a multidisciplinary team • Highly organized with strong attention to detail • Inclusion of a coding portfolio as part of the application (a link to GitHub repository is preferred) • At least 2 years of experience in the pharmaceutical or biotechnology industry, with a focus on antibody drug discovery and development or infectious diseases • Experience with SARS-CoV-2 research or similar virology-related projects • Experience in regulatory interactions and patenting strategies Company Overview • Invivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections. It was founded in 2020, and is headquartered in Waltham, Massachusetts, USA, with a workforce of 51-200 employees. Its website is Apply tot his job